ONE-POT SYNTHESIS OF NEW IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES

摘要

New imidazo[l,2-a]pyridine and imidazo[l,2-a]pyrimidine derivatives were easily obtained by an one-pot synthesis that implies the reaction of the corresponding 2-aminoheterocycles with N,N-dimethylformamide dimethylacetal (DMFDMA),followed by the reaction of intermediate N-heteroarylformamidine (without isolation) with reactive alpha-halocarbonyl compounds.In this way,new 3-substituted imidazo[l,2-a]pyridine and imidazo[l,2-a]pyrimidine derivatives were obtained.