THE MUTAGENIC EFFECTS OF ANTHRACYCLINES IN THE BACTERIUM SALMONELLA TYPHIMURIUM: INDUCTION OF TRANSITION MUTATIONS WITH DAUNOMYCIN

摘要

This study examined the mutagenic effects of the anthracycline daunomycin in a new set of Salmonella strains. Results show that daunomycin can induce base- substitution transition mutations in Salmonella typhimurium. Specifically, frameshift mutations (TA98) were induced 44.6-fold. AT to GC transition mutations (TA7001) were induced 7.3-fold and GC to AT transition events (TA7004) were induced 7.6-fold. Thus, it appears that daunomycin can induce a wide array of mutational events which include frameshifts and base-substitution mutations.