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Electrochemical serotonin sensing interface based on double-layered membrane of reduced graphene oxide/polyaniline nanocomposites and molecularly imprinted polymers embedded with gold nanoparticles

机译:基于氧化石墨烯/聚苯胺纳米复合材料双层膜和嵌入金纳米粒子的分子印迹聚合物的电化学5-羟色胺传感界面

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摘要

A double-layered membrane sensing interface was fabricated for sensitive and selective detection of serotonin (5-hydroxytryptamine, 5-HT) based on reduced graphene oxide (rGO)/polyaniline (PANI) nanocomposites and molecularly imprinted polymers (MIPs) embedded with gold nanoparticles (AuNPs). rGO/PANI nanocomposites were synthesized via electro-deposition process, in which protonated anilines were first anchored on the rGO sheets through electrostatic adsorption, and then the rGO/PANI membrane was formed on the bare electrode via cyclic voltammetry method. Functionalized AuNPs (F-AuNPs) were prepared to fabricate the MIPs embedded with AuNPs (AuNPs@MIPs) membrane on the modified electrode by constant potential method in the presence of 5-HT and p-aminothiophenol. The materials prepared in this work were examined by ultraviolet-visible (UV-Vis) and Raman spectroscopy, and the as-prepared membranes were characterized by scanning electron microscope, energy dispersive spectroscopy, and electrochemical methods. In addition, the obtained sensor allowed remarkable selectivity to 5-HT against the interferences caused by ascorbic acid and other interferents. A linear dependence of peak current in differential pulse voltammograms was obtained over 0.2-10.0 μmol L~(-1) 5-HT with the limit of detection of 11.7 nmol L~(-1) (S/N = 3). Furthermore, the obtained biomimetic sensor was employed to detect 5-HT in human serum samples.
机译:制备了双层膜传感界面,用于基于还原的氧化石墨烯(rGO)/聚苯胺(PANI)纳米复合材料和嵌入金纳米颗粒的分子印迹聚合物(MIP)来敏感和选择性地检测5-羟色胺(5-羟色胺,5-HT) (AuNP)。通过电沉积法合成rGO / PANI纳米复合材料,首先通过静电吸附将质子化苯胺固定在rGO板上,然后通过循环伏安法在裸电极上形成rGO / PANI膜。制备了功能化的AuNPs(F-AuNPs)以在5-HT和对氨基硫酚的存在下通过恒电位方法在修饰电极上制备嵌入AuNPs(AuNPs @ MIPs)膜的MIP。通过紫外-可见(UV-Vis)和拉曼光谱检查了这项工作中制备的材料,并通过扫描电子显微镜,能量色散光谱和电化学方法对制得的膜进行了表征。另外,获得的传感器对由抗坏血酸和其他干扰物引起的干扰具有显着的对5-HT的选择性。在0.2-10.0μmolL〜(-1)5-HT上获得差分脉冲伏安图中峰值电流的线性关系,检出限为11.7 nmol L〜(-1)(S / N = 3)。此外,将获得的仿生传感器用于检测人血清样品中的5-HT。

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