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Coaxial microneedle-electrode for multichannel and local-differential recordings of neuronal activity

机译:用于多通道的同轴微针电极和神经元活动的局部差分记录

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摘要

Electrophysiological recording requires low invasive electrode geometry in the tissue and high-quality signal acquisitions. Here we propose a < 10-μm diameter coaxial cable-inspired needle electrode, which consists of a core electrode in the needle surrounded by another shell electrode. The neuronal recording capability of these electrodes was confirmed by multichannel recording of a mouse cortex in vivo. Given that the shell electrode played the role of a reference electrode, the coaxial electrode also enabled a differential recording at the local area within the tissue. Compared to the recording without the referenced shell electrode, the differential recording demonstrated a twofold higher signal-to-noise ratio, while the firing rate increased. These results suggest that the coaxial microneedle-electrode will provide high-quality neuronal signals in electrophysiological recordings including ex vivo and in vitro applications, similar to the in vivo recording.
机译:电生理记录需要组织中的低侵入电极几何形状和高质量的信号采集。在这里,我们提出了一种直径<10μm的直径同轴电缆启动针电极,其由由另一个壳电极包围的针中的芯电极组成。通过体内测定小鼠皮质的多通道记录来证实这些电极的神经元记录能力。鉴于壳体电极发挥着参比电极的作用,同轴电电极还使在组织内的局部区域能够差动记录。与没有参考壳电极的记录相比,差分记录显示出双重的信噪比,而射击率增加。这些结果表明同轴微针电极将在包括离体和体外应用的电生理记录中提供高质量的神经元信号,类似于体内记录。

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  • 来源
    《Sensors and Actuators》 |2020年第10期|128442.1-128442.8|共8页
  • 作者单位

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Industrial Engineering Mechanical and Control Engineering Course National Institute of Technology Ibaraki College Ibaraki 312-8508 Japan;

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Applied Chemistry and Life science Toyohashi University of Technology Toyohashi 441-8580 Japan Electronics-Inspired Interdisciplinary Research Institute Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Electronics-Inspired Interdisciplinary Research Institute Toyohashi University of Technology Toyohashi 441-8580 Japan Department of Computer science and Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

    Department of Electrical and Electronic Information Engineering Toyohashi University of Technology Toyohashi 441-8580 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microelectrode; Neural recording; Multichannel recording; Differential recording;

    机译:微电极;神经记录;多通道记录;差分记录;

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