SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF CERTAIN NEW 1,2,3-TRIARYL-2,3-DIHYDRO-4(1H)- QUINAZOLINONES

摘要

A series of 1,2,3-triaryl-2,3-dihydro-4(1H)-quinazolinones, 4a-e, Sa-e, 6a-e, 7a-e, 8a-d and 9a-d was prepared. The structures of the prepared compound were established from their analytical data, 1R spectra, ~1H-NMR and mass spectroscopy. Compounds 4a, 4b, 4c, 5b, 5c, 5d, 6a, 6b, 6d, 7a, 7b, 7c, 8a, 8b, 8c, 9a and 9b were tested for antiinflammatory activity in the rat paw edema test. The results revealed that compounds 9b, 9a, 7a and 7b produced significant antiiflammatory activity at a dose of 100 mg/kg, i.e, about 30-70% inhibition of edema. Whereas, flufenamic acid at a dose of 10 mg/kg caused 70% inhibition.