RGS-PX1, a GAP for Gα_s and Sorting Nexin in Vesicular Trafficking

摘要

Heterotrimeric GTP-binding proteins (G proteins) control cellular functions by Transducing signals from the outside to the inside of cells. Regulator of G protein Signaling (RGS) proteins are key modulators of the amplitude and duration of G protein-mediated signaling through their ability to serve as guanosine Triphosphatase-activating proteins (GAPs). We have identified RGS-PX1, a Gα_s- Specific GAP. The RGS domain of RGS-PX1 specifically interacted with G_αs, Accelerated its GTP hydrolysis, and attenuated G_αs -mediated signaling.