Efficient Fluorination of Organic Molecules with Chiral Anions

摘要

Many pharmaceuticals and agro-chemicals, as well as liquid-crystal materials, contain fluorine atoms. The introduction of the small, highly electronegative fluorine atom into an organic molecule can greatly change its physical and biological properties and, with careful design, improve its chemical and metabolic stability as well as its biological activity (7). In many cases, fluorine has been introduced on an aromatic ring or as a triflu-oromethyl group, but fluorine substitution at a chiral carbon center—one that has right- or left-handed stereochemistry—is attracting increasing attention, because adding a fluorine atom to a chiral center can alter the conformation of the molecule and allow fine-tuning of its biological activities.