Use It, Then Lose It

摘要

Pathogenic bacteria encode effector proteins that AMPylate (covalently attach adenosine mo-nophosphate to) target host factors such as Rho or Rab guanosine triphosphatases. AMPylation interferes with downstream signaling events, thereby promoting microbial infection. How AMPylation of host factors is regulated during infection and if it can be reversed within cells is unclear. Neunuebel et al.