Much-Needed Neurogenesis

摘要

Destruction of nervous tissue, such as what occurs during stroke, traumatic brain injury, or neurodegeneration, usually causes deficits and malfunctions. However, brain injury can also stimulate plasticity. Perederiy et al. created unilateral lesions of the perforant path in the hippocampus in a mouse model and observed the response of newborn granule cells that were dividing at the time of the lesion. Using trans-genic and retroviral labelling techniques, these cells could be followed and traced over the coming days and weeks. Chronic denervation triggered the proliferation of adult-generated neurons.