Trial of New Oral Antidiabetic Agent Provides Both Answers and More Questions

摘要

Protocols for clinical trials are drawn up (and their results analyzed and reported) following strict guidelines. These include calculation of trial size, which involves assumptions about what benefit the test drug might achieve. However, even the best designs sometimes yield results that are tanta-lizingly short of conventional statistical significance. The PROspective pioglitAzone Clinical Trial in Macrovascular Events (PROactive) illustrates this frustration (paper #7).