Associations of long-term exposure to air pollutants, physical activity and platelet traits of cardiovascular risk in a rural Chinese population

摘要

Background: Long-term exposure to air pollutants relate to increase risk of cardiovascular diseases that may be partially attributable to platelet dysfunction. Physical activity (PA) may attenuate inflammation to modulate platelet function. Thus, this study aimed to evaluate associations of air pollutants and PA with platelet traits of cardiovascular risk. Methods: A total of 31,282 participants were obtained from the Henan Rural Cohort (n = 39,259).The concentrations of particulate matter (PM) (PM with an aerodynamic diameter ≤1.0 μm (PM_1),＜2.5 μm (PM_(2.5)),or＜10μm (PM_(10))) and nitrogen dioxide (NO_2) were evaluated by using a spatiotemporal model incorporated into satellites data. Independent and combined effects of air pollutants and PA on platelet traits were analyzed by linear mixed models. Results: Positive associations of PM_1, PM_(2.5), PM_(10) and NO_2 with platelet indices (mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR), the MPV to platelet counts (PLT) ratio (MPVP)) were observed, whereas negative associations of PM_(10) and NO_2 with PLT or plateletcrit (PCT) were observed; negative interaction effects of PM2.5 PM10 and NO_2 and PA on MPV, PDW or P-LCR were found; negative interaction effects of PM_1, PM_(2.5) and PM_(10) and PA on PCT were observed. Conclusions: Long-term exposure to air pollutants were related to increase platelet size and these associations were attenuated by increased PA, implying that PA is a costless and affordable method to decrease adverse effects on platelet traits in relation to air pollutants.