Kinetics of low threshold calcium channels of relay cells in cat lateral geniculate nucleus

摘要

Kinetics of the low threshold T-type Ca~(2+) channel is studied with single electrode voltage damp technique on brain slices of the cat lateral geniculate nucleus (LGN). Space damp is dramatically improved by blocking various K~+ and Na~+ channels, decreasing Ca~(2+) current and selecting proper holding potentials. Results from this study, are similar to those obtained from acutely dissociated LGN neurons of the rat, indicating that the kinetics of T-Ca~(2+) channels of the cat LGN neurons is the same as that of the rat LGN. The result reported previously on the cat LGN may result from a defect in space damp.