The Nobel Prize in Physiology or Medicine for the year 2002 was jointly awarded to Sydney Brenner of UK, H. Robert Horvitz of USA and John E. Sulston of UK, for their significant discoveries concerning genetic regulation of organ development and programmed cell death using C. elegans as model organism. The Nobel Committee in their citation said that this year's Nobel Laureates in Physiology or Medicine have made seminal discoveries concerning the genetic regulation of organ development and programmed cell death. By establishing and using the nematode C. elegans as an experimental model system, possibilities were opened to follow cell division and differentiation from the fertilized egg to the adult. The laureates trio have identified key genes regulating organ development and programmed cell death and have shown that corresponding genes exist in higher species, including man. The discoveries are important for medical research and have shed new light on the pathogenesis of many diseases.
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机译：2002年诺贝尔生理学或医学奖由英国的Sydney Brenner，美国的H. Robert Horvitz和英国的John E. Sulston共同颁发，以表彰他们在利用C进行器官发育的遗传调控和程序性细胞死亡方面的重大发现。线虫作为模型生物。诺贝尔委员会在引用中指出，今年的诺贝尔生理学或医学奖获得者在器官发育和程序性细胞死亡的遗传调控方面取得了开创性的发现。通过建立和使用线虫秀丽隐杆线虫作为实验模型系统，打开了跟踪受精卵到成年细胞分裂和分化的可能性。三位获奖者已经确定了调节器官发育和程序性细胞死亡的关键基因，并表明相应的基因存在于包括人类在内的更高物种中。这些发现对医学研究很重要，并且为许多疾病的发病机理提供了新的启示。
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