L-GULONATE DEHYDROGENASE : A COMMON REGULATORY TARGET IN DIABETIC NEPHROPATHY, RETINOPATHY, AND IN OVARIAN FUNCTION

摘要

Nutritional studies on humans and animals have long back established the role of vitamins and mineral elements in health1. For many phylogenic groups these are essential I.e. they have to be supplied in the diet as, such organisms like humans have lost the ability to biosynthesize these dietary components. While a lot of biochemical work has been done on the dietary carbohydrate, protein and lipid metabolism in generating, storing and utilizing energy for living processes2, the metabolic link between the biochemical reaction in which the vitamin takes part and the disease precipitated in their absence is not clearly understood. This is true for many genetic disorders also where establishing cause and effect metabolic link between gene defect and a phenotype like mental disorder is proving to be difficult.