Pareto frontier visualization in multi-criteria search for efficient therapy strategies: HIV infection example

摘要

Visualization of the Pareto frontier is a new approach in multi-criteria decision making, i.e. searching for efficient decisions taking multiple decision criteria into account. In this paper, visualization of the Pareto frontier is used in the process of multi-criteria search for efficient strategies of HIV therapy. By using a non-linear mathematical model of virus dynamics, which takes into account the phenomenon of virus variability under the influence of a drug, we show that in the framework of the model it is possible to construct a therapy strategy that balances the conflicting requirements imposed on the therapy process.