STATISTICAL APPROACH TO DETERMINE PHASE TRANSITIONS OF THE RYANODINE RECEPTOR

摘要

Two statistical models are developed to fit time dependent ryanodine binding to sarcoplasmic reticulum vesicles as a function of temperature over the temperature range of. 23℃ to 40℃. Both using correlation coefficients and error risk analysis, it was concluded that under oxidizing conditions there is a break in the Arrhenius plot (i.e. a phase transition) at approximately 34℃. The accuracy of the determination of the phase transition temperature was also examined.