TOPIRAMATE AS PROPHYLACTIC TREATMENT IN MIGRAINE: TOPIRAMATE NELLA TERAPIA DI PROFILASSI DELL'EMICRANIA

摘要

Topiramate is a novel antiepileptic drug (AED) which exerts its action through (1) blocking of voltage gated sodium channel, (2) increase of GABAA recep- activity through stimulation of the non benzodiazepine site of the GABAA recep- tors, (3) antagonising the glutamate kainate/AMPA receptor.