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Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome

机译:弥漫性增生性肾小球肾炎合并伴有肾病综合征的皮肌炎

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摘要

We described a 44-year-old man developing dermatomyositis (DM) and nephrotic syndrome (NS). Renal biopsy revealed diffuse proliferative glomerulonephritis (DPGN) with depositions of immunoglobulin and complements. A combination therapy of steroid and cyclophosphamide (CTX) was found very effective for the patient. Chronic glomerulonephritis is rare in DM. In our review of related literature, membranous glomerulonephritis (MN) is the main type of glomerular lesion, another type is mesangial proliferative glomerulonephritis (mesPGN). Here we reported a case of DM associated with DPGN developing NS, which was not found in existing literature. Although glomerulonephritis is uncommon in patients with DM, renal pathology is not as simplex as previously thought, and treatment with steroid or/and cytotoxic drugs is favorable for prognosis.
机译:我们描述了一个44岁的男子,患上皮肌炎(DM)和肾病综合征(NS)。肾脏活检显示弥漫性增生性肾小球肾炎(DPGN)伴有免疫球蛋白和补体沉积。发现类固醇和环磷酰胺(CTX)的联合疗法对患者非常有效。慢性肾小球肾炎在DM中很少见。在我们的相关文献综述中,膜性肾小球肾炎(MN)是肾小球病变的主要类型,另一种是肾小球膜增生性肾小球肾炎(mesPGN)。在这里,我们报道了与DPGN发展为NS相关的DM病例,在现有文献中未发现。尽管肾小球肾炎在DM患者中并不常见,但肾脏病理学并不像以前认为的简单,并且使用类固醇或/和细胞毒性药物治疗对预后有利。

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