Serum Amyloid A and Its Potential Physiological / Pathological Functions - an Overview of Patents

摘要

Abstract: Serum amyloid A (SAA) and its protein family are highly conserved acute phase proteins elevated to high nlevels during acute inflammation. Among the many different roles SAA plays, one of the major ones is believed to be the nregulation of mechanisms designed to fight injuries, heal infections and bring about their resolution to homeostasis. In the ncirculation, SAA is mainly associated with high density lipoproteins, can influence cholesterol transport and has been nimplicated in the pathogenesis of atherosclerosis, rheumatoid arthritis, and cancer. The deposition of SAA cleavage nproducts can lead to amyloidosis. So, patents describing possible modifications of SAA pathophysiological role/s are nrelevant. SAA is one of the highest positively responsive acute phase proteins in humans, as well as in animals, and its nlevels have been used to monitor diseases, treatment strategies and predict outcomes. The major aims of this overview nwere to determine the potential for SAA as a diagnostic tool (in terms of SAA secretion as a cause or consequence of ndisease) and to critically analyse patents proposing SAA measurement methodologies, in order to determine the most noptimal. A compilement of SAA patents predominantly generated within the past decade will also enable a better nunderstanding of SAA, its genetics, the expression of its isoforms, associations with other proteins, especially its nreceptors, which could be important in diagnosis and/or treatment of chronic inflammatory diseases.