Pulse and gamma radiolytic studies of the radiosensitizer sanazole (AK-2123) in presence of uracil

摘要

Radiolytic studies on sanazole, an efficient hypoxic cell radiosensitizer generally referred to as AK-2123, revealed that its reactions with e_aq and OH radicals yield transients with λ_max at 295 and 290 nm and their respective bi-molecular rate constants are 3.6x10~10 dm~3 mol~1 s~1 and 1.55 x 10~8 dm~3 mol~1 s~1. Preliminary studies on steady state gamma radiolysis of the drug in presence of uracil indicate electron transfer from the pyrimidine based to AK-2123.