Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats

Leandro J. Bertoglio; Antonio P. Carobrez

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Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats

机译：在大鼠进行高迷宫试验2期间，NMDA /甘氨酸B受体配体的抗焦虑作用消失了

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摘要

Drugs enhancing the GABAA and/or reducing the NMDA/glycine-B receptor activity produce an anxiolytic effect. Regarding the former drugs (e.g. benzodiazepines), prior elevated plus-maze (EPM) test experience abolishes the trial 2 anxiolytic activity, a phenomenon referred to as "one-trial tolerance" (OTT).

机译：增强GABAA 和/或降低NMDA /甘氨酸B受体活性的药物可产生抗焦虑作用。对于以前的药物（例如苯二氮卓类药物），先前的高迷宫试验（EPM）取消了试验2的抗焦虑活性，这种现象被称为“一次试验耐受性”（OTT）。

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来源
《Psychopharmacology》 |2003年第4期|335-342|共8页
作者
Leandro J. Bertoglio; Antonio P. Carobrez;
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作者单位

Departamento de Farmacologia CCB Universidade Federal de Santa Catarina;

Departamento de Farmacologia CCB Universidade Federal de Santa Catarina;

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正文语种 eng
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关键词
Anxiety; Elevated plus-maze; One-trial tolerance; NMDA antagonist; Glycine-B antagonist;

机译：焦虑;迷宫增强;一次试验耐受;NMDA拮抗剂;甘氨酸B拮抗剂;

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1. Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats. [J] . Bertoglio LJ, Carobrez AP Psychopharmacology . 2003,第4期

机译：在增加的迷宫试验2中，NMDA /甘氨酸B受体配体的抗焦虑作用消失了。
2. NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats [J] . Zhou Heng, Yu Cheng-Long, Wang Li-Ping, Pharmacology, Biochemistry and Behavior . 2015,第Null期

机译：在升高的迷宫试验中，NMDA和D1受体参与了对地西m抗焦虑样作用的一审耐受
3. Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats. [J] . Santos P, Bittencourt AS, Schenberg LC, Neuropharmacology . 2006,第2期

机译：T迷宫评估NMDA /甘氨酸-B位配体注入背导水周灰质和大鼠上丘的焦虑和记忆效应。
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Antidepressant and anxiolytic-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats. [D] . Carr, Gregory Vernon. 2009

机译：κ-阿片受体拮抗剂在Wistar Kyoto大鼠中的抗抑郁和抗焦虑作用。
6. Anxiolytic-like Effects of the Neurokinin 1 Receptor Antagonist GR-205171 in the Elevated Plus-Maze and Contextual Fear-Potentiated Startle Model of Anxiety in Gerbils [O] . Scott A. Heldt, Michael Davis, Emiliangelo Ratti, -1

机译：神经喹啉1受体拮抗剂GR-205171在升高的加迷宫和上下文恐惧调高的焦虑症中焦虑症中的抗焦虑效应
7. Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT₂/5-HT₃/5-HT₄ ligands [O] . Bell, Rob, Duke, Aaron A., Gilmore, Paula E., 2014

机译：用5-HT _{2 / 5-HT _{3 / 5-HT _{4 处理后暴露于零迷宫升高的大鼠中观察到抗焦虑样作用sub>配体}}}

Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats

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