Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge

Daniel H. Wolf; Theodore D. Satterthwaite; James Loughead; Amy Pinkham; Eve Overton; Mark A. Elliott; Gersham W. Dent; Mark A. Smith; Ruben C. Gur; Raquel E. Gur

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Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge

机译：苯二氮卓类药物掩盖的精神分裂症患者一级亲属的杏仁核异常

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Impaired emotion processing in schizophrenia predicts broader social dysfunction and has been related to negative symptom severity and amygdala dysfunction. Pharmacological modulation of emotion-processing deficits and related neural abnormalities may provide useful phenotypes for pathophysiological investigation.

机译：精神分裂症的情绪加工受损预示着更广泛的社会功能障碍，并与负面症状严重程度和杏仁核功能障碍有关。情绪处理缺陷和相关神经异常的药理学调节可为病理生理学研究提供有用的表型。

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来源
《Psychopharmacology》 |2011年第3期|p.503-512|共10页
作者
Daniel H. Wolf; Theodore D. Satterthwaite; James Loughead; Amy Pinkham; Eve Overton; Mark A. Elliott; Gersham W. Dent; Mark A. Smith; Ruben C. Gur; Raquel E. Gur;
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作者单位

Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg., 3400 Spruce St., Philadelphia, PA, 19104, USA;

Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg., 3400 Spruce St., Philadelphia, PA, 19104, USA;

Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg., 3400 Spruce St., Philadelphia, PA, 19104, USA;

Department of Psychology, Southern Methodist University, Dallas, TX, 75275, USA;

Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg., 3400 Spruce St., Philadelphia, PA, 19104, USA;

Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA;

AstraZeneca Pharmaceuticals LP, Wilmington, DE, 19850, USA;

AstraZeneca Pharmaceuticals LP, Wilmington, DE, 19850, USA;

Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg., 3400 Spruce St., Philadelphia, PA, 19104,;

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正文语种 eng
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关键词
Pharmacological fMRI; Benzodiazepine; Endophenotype; Amygdala; Facial emotion; GABA; Schizophrenia;

机译：药理学功能磁共振成像;苯二氮卓;表型;杏仁核;面部情感;GABA;精神分裂症;

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专利

1. Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge. [J] . Wolf DH, Satterthwaite TD, Loughead J, Psychopharmacology . 2011,第3期

机译：精神分裂症患者一级亲属中的杏仁核异常未通过苯二氮卓激发而掩盖。
2. Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia. [J] . Vigo Daniel E, Chu Elvina M, Fahrer Rodolfo D, Schizophrenia research . 2009,第1a3期

机译：精神分裂症患者一级亲属对心理算术压力的心率变异性反应异常。
3. Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia. [J] . Horan WP, Braff DL, Nuechterlein KH, Schizophrenia research . 2008,第1a3期

机译：精神分裂症患者及其一级亲属的口头工作记忆障碍：精神分裂症遗传学联合会的发现。
4. A Preliminary Study of Memory Functions in Unaffected First-Degree Relatives of Schizophrenia [C] . Xiao-Yan Cao, Zhi Li, Raymond C.K. Chan International conference on intelligent computing . 2013

机译：精神分裂症未受影响的一级亲属的记忆功能的初步研究
5. Behavioral and Electrophysiological Correlates of Context Processing in Individuals with Schizophrenia and Their First-Degree Relatives. [D] . Jones, Jessica Ann Hurdelbrink. 2011

机译：精神分裂症患者及其一级亲属的情境处理的行为和电生理相关性。
6. Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge [O] . Daniel H. Wolf, Theodore D. Satterthwaite, James Loughead, -1

机译：Amygdala在苯齐齐卓挑战挑战挑战中占精神分裂症的一级亲属的异常
7. Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge [O] . Daniel H. Wolf, Theodore D. Satterthwaite, James Loughead, 2011

机译：Amygdala在苯齐齐卓挑战挑战挑战中占精神分裂症的一级亲属的异常

Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge

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