Depression und Psychose in der Menopause - kann eine Hormontherapie hilfreich sein?

摘要

Menopause can severely influence mental wellbeing of women. Mental disorders such as depression or psychoses show an excess incidence in this time or deterioration of course. This is probably not only due to the manifold psychosocial and physiological changes women have to deal with in this age group, but also specifically with the physiological loss of estrogen production. Estrogens, and specifically estradiol-17-β show important neuro- and psychoprotective properties. Regarding therapy of these disorders, besides psychopharmacotherapy, psychotherapy and social measures, in some cases also substitution of estradiol-17-β has to be taken into account. In this case, certain risks have to be considered and indications as well as contraindications have to be carefully assessed in cooperation with a gynecologist.