Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

David M. Holtzman; Kelly R. Bales; Tanya Tenkoval

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

机译：载脂蛋白E亚型依赖性淀粉样蛋白沉积和神经变性在阿尔茨海默氏病小鼠模型中

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Apolipoprotein E (apoE) alleles determine the age-adjusted rela- tive risk (ε4 > ε3) for Alzheimer's disease (AD). ApoE may affect AD pathogenesis by promoting deposition of the amyloid-β (Aβ) peptide and its conversion to a fibrillar form. To determine the effect of apoE on Ap deposition and AD pathology, we compared

机译：载脂蛋白E（apoE）等位基因决定了阿尔茨海默氏病（AD）的年龄校正后相对风险（ε4>ε3）。 ApoE可能通过促进淀粉样β（Aβ）肽的沉积及其转化为原纤维形式来影响AD发病机制。为了确定apoE对Ap沉积和AD病理的影响，我们比较了

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《Proceedings of the National Academy of Sciences of the United States of America》 |2000年第6期|p.2892-2897|共6页
作者
David M. Holtzman; Kelly R. Bales; Tanya Tenkoval;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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入库时间 2022-08-18 00:47:47

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1. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. [J] . Costa DA, Nilsson LN, Bales KR, Journal of Alzheimer's disease: JAD . 2004,第5期

机译：在阿尔茨海默氏病的AbetaPP / PS双转基因小鼠模型中，载脂蛋白是形成丝状淀粉样蛋白所必需的，而无定形Abeta沉积则不需要。
2. Apolipoprotein E Dose-Dependent Modulation of beta-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease. [J] . DeMattos RB Journal of Molecular Neuroscience: MN . 2004,第3期

机译：载脂蛋白E剂量依赖性的阿尔茨海默氏病转基因小鼠模型中β-淀粉样蛋白沉积的调节。
3. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. [J] . Hartman RE, Laurer H, Longhi L, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第23期

机译：在阿尔茨海默氏病小鼠模型中，创伤性脑损伤后载脂蛋白E4影响淀粉样蛋白沉积，但不影响细胞丢失。
4. Mimotope Peptides of Amyloid-B42 Fibril-Specific Antibodies Bind to Amyloid Plaques in Brain Sections of Alzheimer's Disease Model Mouse, J20 [C] . Koichi Tanaka, Risa Abe, Yuya Yamaguchi Japanese peptide symposium . 2011

机译：淀粉样蛋白-B42纤维特异性抗体的模拟物肽与阿尔茨海默病模型小鼠的脑切片中的淀粉样蛋白斑块结合，J20
5. Chronic Traffic Noise Exposure Contributes to Emergence of Cognitive and Motor Functions Impairment and Increases Amyloid-β Deposition in Mouse Model of Alzheimer’s Disease [D] . Karem, Hadil 2019

机译：慢性交通噪声暴露导致认知和运动功能障碍的出现，并增加了阿尔茨海默氏病小鼠模型中的淀粉样蛋白-β沉积
6. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimers disease [O] . David M. Holtzman, Kelly R. Bales, Tanya Tenkova, 2000

机译：载脂蛋白E亚型依赖的淀粉样蛋白沉积和阿尔茨海默氏病小鼠模型中的神经变性
7. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease [O] . Holtzman, David M., Bales, Kelly R., Tenkova, Tanya, 2000

机译：载脂蛋白E亚型依赖的淀粉样蛋白沉积和阿尔茨海默氏病小鼠模型中的神经变性

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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