Frotective DNA vaccination against organ-specific autoimmunitv is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

摘要

DNA vaccines that encode encephalitogenic sequences in tandem can protect from subsequent experimental autoimmune enceph- alomyelitis induced with the corresponding peptide. The mecha- nism for this protection and, in particular, if it is specific for the amino acid sequence encoding the vaccine are not known.