DNA repair on the brain

摘要

Xeroderma pigmentosum (XP), Cock- ayne syndrome (CS), and trichothio- dystrophy (TTD) constitute a family of sun-sensitive human diseases (1). They are caused by mutations in the components of the nucleotide excision repair (NER) sys- tem and in the postreplication repair sys- tem involving the low-fidelity polymerase H (also known as XP variant or XPV). XP was initially recognized as a disease in- volving a genetic predisposition to ex- tremely high levels of skin carcinogenesis from solar exposure.