Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

摘要

Understanding the gene-expression patterns during liver regenera- tion may help to reveal how regenerative processes are initiated and controlled as well as shed new light onto processes that lead to liver disease. Using high-density oligonucleotide arrays, we have exam- ined the gene-expression program in the livers of mice after partial hepatectomy. A time course was constructed for gene expression between 0 and 4 h after partial hepatectomy, corresponding to the priming phase of liver regeneration. The genomic program for liver regeneration involves transcription-factor generation, stress and in- flammatory responses, cytoskeletal and extracellular matrix modify- cation, and regulation of cell-cycle entry.