Phospholipase Cβ3 In Mouse And Human Dorsal Root Ganglia And Spinal Cord Is A Possible Target For Treatment Of Neuropathic Pain

摘要

Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase β3 (PLCβ3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.