Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

Yan Yang; Satoru Yuzawa; Joseph Schlessinger

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Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

机译：PDGF受体胞外域的膜近端区域之间的接触对于受体激活是必需的，但对于受体二聚化则不是必需的

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The mechanism of PDGF-receptor β (PDGFRβ) activation was explored by analyzing the properties of mutant receptors designed based on the crystal structure of the extracellular region of the related receptor tyrosine kinase KIT/stem cell factor receptor. He

机译：通过分析基于相关受体酪氨酸激酶KIT /干细胞因子受体的细胞外区域的晶体结构设计的突变受体的特性，探索了PDGF-受体β（PDGFRβ）激活的机制。他

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第22期|7681-7686|共6页
作者
Yan Yang; Satoru Yuzawa; Joseph Schlessinger;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
cell proliferation; cell signaling; phosphorylation; surface receptors tyrosine kinases;

机译：细胞增殖;细胞信号;磷酸化表面受体酪氨酸激酶;
入库时间 2022-08-18 00:43:31

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1. Direct contacts between extracellular membrane- proximal domains are required for VEGF receptor activation and cell signaling [J] . Yan Yang, Peng Xie, Yarden Opatowsky, Proceedings of the National Academy of Sciences of the United States of America . 2010,第5期

机译：VEGF受体激活和细胞信号传导需要细胞外膜近端结构域之间的直接接触
2. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. [J] . F W Quelle, N Sato, B A Witthuhn, Molecular and Cellular Biology . 1994,第7期

机译：JAK2与粒细胞-巨噬细胞集落刺激因子受体的βc链相关，其激活需要膜近端区域。
3. Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization [J] . Sum Shing Chi, Sandra M Vetiska, Robin S Gill, Molecular brain . 2010,第1期

机译：多巴胺D4受体对PDGFRβ的反式激活不需要PDGFRβ二聚化
4. Tethering of the proximal region of the angiotensin II receptor (AT_(1A) C-terminus to the cell membrane [C] . Henriette Mozsolits, Sharon Unabia, Walter G.Thomas, the International Peptide Symposium . 2001

机译：血管紧张素II受体的近端区域的束缚（AT_（1A）C-末端到细胞膜
5. The role of dimerization and trimerization in alpha helical membrane protein folding: Insights into receptor activation and viral envelope protein activation. [D] . Matthews, Erin Elizabeth. 2007

机译：二聚化和三聚化在α螺旋膜蛋白折叠中的作用：洞察受体激活和病毒包膜蛋白激活。
6. Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization [O] . Yan Yang, Satoru Yuzawa, Joseph Schlessinger 2008

机译：PDGF受体胞外域的膜近端区域之间的接触对于受体激活是必需的但对于受体二聚化则不是必需的
7. Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization [O] . Yang, Yan, Yuzawa, Satoru, Schlessinger, Joseph 2008

机译：PDGF受体胞外域的膜近端区域之间的接触对于受体激活是必需的，但对于受体二聚化则不是必需的

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

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