Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

摘要

Acetylchohne-binding proteins (AChBPs) from mollusks are suitable structural and functional surrogates of the nicotinic acetyl-choline receptors when combined with transmembrane spans of the nicotinic receptor. These proteins assemble as a pentamer with i