The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

Shilpa Oak; Lisa K. Gilliam; Mona Landin-Olsson; Carina Toern; Ingrid Kockum; Christina R. Pennington; Merrill J. Rowley; Michael R. Christie; J. Paul Banga; Christiane S. Hampe

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The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

机译：缺乏抗独特型抗体，不存在针对谷氨酸脱羧酶的相应自身抗体，定义了1型糖尿病

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Autoantibodies to glutamate decarboxylase 65 (GAD65Ab) are commonly believed to be a major characteristic for type 1 diabetes (T1D). We investigated the presence of GAD65Ab in healthy individuals (n = 238) and first-degree relatives (FDRs) of T1D patients

机译：通常认为，针对谷氨酸脱羧酶65（GAD65Ab）的自身抗体是1型糖尿病（T1D）的主要特征。我们调查了健康个体（n = 238）和T1D患者的一级亲属（FDR）中GAD65Ab的存在

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第14期|5471-5476|共6页
作者
Shilpa Oak; Lisa K. Gilliam; Mona Landin-Olsson; Carina Toern; Ingrid Kockum; Christina R. Pennington; Merrill J. Rowley; Michael R. Christie; J. Paul Banga; Christiane S. Hampe;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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入库时间 2022-08-18 00:43:29

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专利

1. The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes [J] . Wyatt R. C., Brigatti C., Liberati D., Diabetic medicine: A journal of the British Diabetic Association . 2018,第7期

机译：谷氨酸脱羧酶的前142个氨基酸不会有助于由与1型糖尿病相关的自身抗体识别的表位
2. Safety and efficacy of autoantigen‐specific therapy with 2 doses of alum‐formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial [J] . Elding Larsson Helena, Lundgren Markus, Jonsdottir Berglind, Pediatric diabetes. . 2018,第3期

机译：自身抗原特异性治疗的安全性和有效性，用多种胰岛素自身抗体和1型糖尿病风险的儿童在儿童中具有2剂的明矾配制谷氨酸脱羧酶：随机临床试验
3. High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: Epitope analysis and inhibition of enzyme activity [J] . HampeC., MaitlandM., GilliamL., Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists . 2013,第4期

机译：1型糖尿病患者中针对谷氨酸脱羧酶的高滴度自身抗体：表位分析和酶活性抑制
4. Detection of Autoantibodies for Type 1 Diabetes Using Label-Free Optical Sensors [C] . Subin Mao, Silu Feng, Long Que 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems amp; Eurosensors XXXIII . 2019

机译：使用无标签光学传感器检测1型糖尿病的自身抗体
5. The role of MHC class II molecules in type I diabetes: An analysis of presentation of glutamic acid decarboxylase 65 by the diabetes-associated HLA-DQ8 molecule. [D] . Herman, Ann Elizabeth. 2000

机译：MHC II类分子在I型糖尿病中的作用：与糖尿病相关的HLA-DQ8分子对谷氨酸脱羧酶65表达的分析。
6. The lack of anti-idiotypic antibodies not the presence of the corresponding autoantibodies to glutamate decarboxylase defines type 1 diabetes [O] . Shilpa Oak, Lisa K. Gilliam, Mona Landin-Olsson, 2008

机译：缺乏抗独特型抗体不存在针对谷氨酸脱羧酶的相应自身抗体定义了1型糖尿病
7. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes [O] . Oak, Shilpa, Gilliam, Lisa K., Landin-Olsson, Mona, 2008

机译：缺乏抗独特型抗体，不存在针对谷氨酸脱羧酶的相应自身抗体，定义了1型糖尿病

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

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