A Critical Role For Il-21 Receptor Signaling In The Pathogenesis Of Systemic Lupus Erythematosus In Bxsb-yaa Mice

摘要

Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that affects the differentiation and function of T, B, and NK cells by binding to a receptor consisting of the common cytokine receptor γ chain and the IL-21 receptor (IL-21R). IL-21, a product associated with IL-17-producing CD4 T cells (T_H17) and follicular CD4 T helper cells (T_(FH)), has been implicated in autoimmune disorders including the severe systemic lupus erythematosus (SLE)-Iike disease characteristic of BXSB-Yaa mice. To determine whether IL-21 plays a significant role in this disease, we compared IL-21R-deficient and -competent BXSB-Yaa mice for multiple parameters of SLE. The deficient mice showed none of the abnormalities characteristic of SLE in IL-21R-competent Yaa mice, including hy-pergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity. IL-21 production associated with this autoimmune disease was not a product of T_H17 cells and was not limited to conventional CXCR5~+ T_(FH) but instead was produced broadly by ICOS~+ CD4~+ splenic T cells. IL-21 arising from an abnormal population of CD4 T cells is thus central to the development of this lethal disease, and, more generally, could play an important role in human SLE and related autoimmune disorders.