Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

摘要

Amyloid-β(Aβ) plaque deposition can precede the clinical manifestations rnof dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. Both the Ap plaque deposition and the changes in metabolism appear to be concentrated in the brain's default-mode network. In contrast to prior studies of brain metabolism which viewed brain metabolism from a unitary perspective that equated glucose utilization with oxygen consumption, rnwe here report on regional glucose use apart from that entering oxidative phosphorylation (so-called "aerobic glycolysis"). Using PET, we found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Ap deposition in individuals with DAT and cognitively normal participants with elevated Ap, sug-.gesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology.