Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases

摘要

Mitotic recombination is required to repair DNA double-strand breaks (DSBs), to restart stalled/collapsed replication forks, and functions as an alternative mechanism to elongate telomeres in cells lacking telomerase. Although these functions preserve genome integrity, mitotic recombination can also cause loss of heterozygosity in cells with polymorphic chromosomes and lead to gross chromosome rearrangements if it occurs between dispersed repeats.