Yet another 'active' pseudokinase, Erb3

摘要

Considerable attention has focused recently on the role of pseudokinases that were assumed to be "dead" protein kinases owing to their lack of one or more key catalytic residues. Erb3 was thought to be one of those kinases that lacked catalytic activity. Shi et al. (1) now demonstrate that Erb3 does, in fact, have residual kinase activity under some conditions. They also show that the activity seems to require what is thought to be an inactive kinase conformation.