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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis
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Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis

机译：天冬氨酸消旋酶，产生神经元D-天冬氨酸，调节成年神经发生

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摘要

D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development and survival of newborn neurons and survival. Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis.
机译：D-天冬氨酸在发育中的大脑中含量丰富。我们已经鉴定并克隆了哺乳动物的天冬氨酸消旋酶（DR），该酶将L-天冬氨酸转化为D-天冬氨酸，并与D-天冬氨酸共定位在大脑和神经内分泌组织中。逆转录病毒介导的成年海马新生神经元中短发夹RNA的表达耗竭DR在新生神经元的树突发育和存活以及存活中引起了深刻的缺陷。由于D-天冬氨酸是NMDA受体的潜在内源性配体，其丢失会引起类似于DR耗竭的表型，因此D-天冬氨酸可作为成人神经发生的调节剂。

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  • 作者

    Paul M. Kim; Xin Duan; Alex S. Huang; Cindy Y. Liu; Guo-li Ming; Hongjun Song; Solomon H. Snyder;

  • 作者单位

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Institute for Cell Engineering,The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Institute for Cell Engineering,The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Institute for Cell Engineering,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Institute for Cell Engineering,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    The Solomon H. Snyder Department of Neuroscience,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Department of Pharmacology and Molecular Sciences,The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    neuronal development; neural progenitor cells; hippocampus; NMDA receptor; neuroendocrine;

    机译：神经元发育神经祖细胞海马NMDA受体;神经内分泌;
  • 入库时间 2022-08-18 00:41:13

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