Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

摘要

Proteins can be modified in various ways and at various times to control their activities within the cell. The addition of a functional group after translation, known as posttranslational modification, can change the way a protein regulates gene transcription. For example, the addition of an acetyl group provides the opportunity for histones- DNA-packaging proteins from which chromatin is composed-to bind to motifs called bromodomains on the surface of chromatin-associated proteins.