Serotonin, cytokines, pll, and depression

摘要

For at least four decades, the field of psychoimmunology has attracted numerous investigators based on diverse hints linking the immune system to emotional behavior. The administration of cytokines for the treatment of various diseases is often associated with depression, which frequently accompanies autoimmune disease. Now, in PNAS, Greengard and colleagues (1) report a specific molecular pathway linking cytokines and the actions of antidepres-sant drugs. Their findings confound es-