Alleles interact in schizophrenia-related phenotypes

摘要

The symptoms and cognitive defects of schizophrenia are thought to involve malfunctioning dopamine D2 receptors, although researchers remain unclear about the exact details of this abnormality. Previous studies suggest that neural activity is compromised when abnormal signaling by D2 receptors disrupts a downstream enzymatic reaction between a pair of protein kinases known as AKT1 and GSK-3β.