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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
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Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

机译：组蛋白去甲基化酶JMJD2C是乳腺癌进展所需的缺氧诱导因子1的共激活因子

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摘要

Activation of hypoxia-inducible factors (HIFs) commonly occurs in many solid tumors as a result of intratumoral hypoxia and/or genetic alterations. HIFs activate transcription of target genes encoding proteins that are involved in critical steps of cancer progression, including angio-genesis, glucose and energy metabolism, cell survival and proliferation, as well as invasion and metastasis (1). Thus, understanding the regulation of HIF tran-scriptional activity may lead to novel therapies for human cancers.
机译：缺氧诱导因子（HIFs）的激活通常发生在许多实体瘤中，这是由于肿瘤内缺氧和/或基因改变引起的。 HIF激活编码蛋白质的靶基因的转录，这些蛋白质参与了癌症进展的关键步骤，包括血管生成，葡萄糖和能量代谢，细胞存活和增殖以及侵袭和转移（1）。因此，了解HIF转录活性的调节可能会导致人类癌症的新疗法。

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    Weibo Luo0; Ryan Chang; Jun Zhong; Akhilesh Pandey; Gregg L. Semenza;

  • 作者单位

    Vascular Program, Institute for Cell Engineering, Departments of The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Biological Chemistry The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Vascular Program, Institute for Cell Engineering, Departments of The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Biological Chemistry The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Biological Chemistry The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Oncology The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Pathology The Johns Hopkins University School of Medicine, Baltimore, MD 21205,McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Vascular Program, Institute for Cell Engineering, Departments of The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Biological Chemistry The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Oncology The Johns Hopkins University School of Medicine, Baltimore, MD 21205,McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Pediatrics The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Medicine, and The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Radiation Oncology, and The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 00:40:33

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