• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Multimodal imaging of the self-regulating developing brain
【24h】

Multimodal imaging of the self-regulating developing brain

机译：自我调节的大脑的多模态成像

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This finding is intriguing, because characteristics of the anterior cingulum are shown to be related to impulse, attention, and executive problems in neurodevelopmental disorders, indicating a neural foundation for self-regulation abilities along a continuum from normality to pathology. The relationship was strongest in the younger children. Properties of large-fiber connections added to the picture by explaining additional variance in cognitive control. Although cognitive control was related to surface area of the anterior cingulate independently of basic processes of mental speed, the relationship between white matter quality and cognitive control could be fully accounted for by speed. The results underscore the need for integration of different aspects of brain maturation to understand the foundations of cognitive development.
机译：自我调节是指控制行为，认知和情绪的能力，而自我调节失败与一系列神经精神病问题有关。人们很少了解大脑的结构成熟如何导致儿童时期自我调节的逐步改善。在大规模的多中心研究中，对735名儿童（4-21岁）进行了结构MRI，以量化皮层厚度和表面积，并进行了弥散张量成像，以量化主要纤维连接的质量。大脑发育与认知控制的标准化措施（美国国立卫生研究院工具箱的侧翼任务）有关，后者是自我调节的重要组成部分。在十一年前，抑制反应和施加认知控制的能力迅速提高。前扣带回皮层的表面积占认知能力差异的很大一部分。这一发现很有趣，因为显示了前扣带的特征与神经发育障碍中的冲动，注意力和执行问题有关，这表明了从正常状态到病理状态的自我调节能力的神经基础。这种关系在年幼的孩子中最牢固。通过解释认知控制中的其他差异，将大光纤连接的属性添加到图片中。尽管认知控制与前扣带的表面积无关，而与心理速度的基本过程无关，但是白质质量与认知控制之间的关系可以通过速度来完全解释。结果强调需要整合大脑成熟的各个方面，以了解认知发展的基础。

著录项

  • 来源
  • 作者

    Anders M. Fjell; Kristine Beate Walhovd; Timothy T. Brown; Joshua M. Kuperman; Yoonho Chung; Donald J. Hagler; Vijay Venkatraman; J. Cooper Roddey; Matthew Erhart; Connor McCabe; Natacha Akshoomoff; David G. Amaral; Cinnamon S. Bloss; Ondrej Libiger; Burcu F. Darst; Nicholas J. Schork; B. J. Casey; Linda Chang; Thomas M. Ernst; Jeffrey R. Gruen; Walter E. Kaufmann; Tal Kenet; Jean Frazier; Sarah S. Murray; Elizabeth R. Sowell; Peter van Zijl; Stewart Mostofsky; Terry L. Jernigan; Anders M. Dale; Genetics Study2;

  • 作者单位

    Department of Psychology, University of Oslo, 0373 Oslo, Norway;

    Department of Psychology, University of Oslo, 0373 Oslo, Norway;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Neurosciences,University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Radiology, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Center for Human Development, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Radiology, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Radiology, University of California at San Diego, La Jolla, CA 92037;

    Center for Human Development, University of California at San Diego, La Jolla, CA 92037;

    Center for Human Development, University of California at San Diego, La Jolla, CA 92037Psychiatry,University of California at San Diego, La Jolla, CA 92037;

    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95817;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA 92037;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA 92037;

    Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY 10065;

    Department of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI 96813;

    Department of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI 96813;

    Departments of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT 06520;

    Kennedy Krieger Institute , Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Children's Hospital Boston, Harvard Medical School, Boston, MA 02115;

    Department of Neurology and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129;

    Department of Psychiatry, University of MassachusettsMedical School, Boston, MA 01655;

    Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA 92037;

    Department of Pediatrics, University of Southern California, Los Angeles, CA 90027 Developmental Cognitive Neuroimaging Laboratory, Children's Hospital, Los Angeles, CA 90027;

    F. M. Kirby Research Center, Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Kennedy Krieger Institute , Kennedy Krieger Institute and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Radiology, University of California at San Diego, La Jolla, CA 92037 Center for Human Development, University of California at San Diego, La Jolla, CA 92037 Psychiatry,University of California at San Diego, La Jolla, CA 92037 Cognitive Science, University of California at San Diego, La Jolla, CA 92037;

    Multimodal Imaging Laboratory, Departments of University of California at San Diego, La Jolla, CA 92037 Neurosciences,University of California at San Diego, La Jolla, CA 92037 Radiology, University of California at San Diego, La Jolla, CA 92037 Psychiatry,University of California at San Diego, La Jolla, CA 92037 Cognitive Science, University of California at San Diego, La Jolla, CA 92037;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    executive function; cognitive conflict; inhibition; morphometry;

    机译：执行功能;认知冲突;抑制;形态学;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号