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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium
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ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

机译：ECM微环境调节正常和恶性乳腺上皮的集体迁移和局部扩散

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摘要

The word "disseminate" is derived from the Latin word disseminare and translated literally means "to scatter seeds." In cancer, tumors disseminate cells to distant sites, providing the seeds for me-tastatic disease. How tumor cells escape from the primary tumor is incompletely understood. It is known that the genotype of the cancer cells and the composition of the extracellular matrix (ECM) change in parallel during the progression of breast cancer (1, 2).
机译：“散布”一词源自拉丁文“ disseminare”，字面意思是“散播种子”。在癌症中，肿瘤将细胞扩散到远处，为转移性疾病提供了种子。肿瘤细胞如何从原发肿瘤中逃逸尚未完全了解。众所周知，在乳腺癌的发展过程中，癌细胞的基因型和细胞外基质（ECM）的组成是平行变化的（1,2）。

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  • 作者

    Kim-Vy Nguyen-Ngoc; Kevin J. Cheung; Audrey Brenot; Eliah R. Shamir; Ryan S. Gray; William C. Hines; Paul Yaswen; Zena Werb; Andrew J. Ewald;

  • 作者单位

    Departments of Cell Biology Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Departments of Oncology, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Departments of Cell Biology Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Departments of Oncology, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Department of Anatomy, University of California, San Francisco, CA 94143;

    Departments of Cell Biology Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Departments of Oncology, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Departments of Cell Biology Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Departments of Oncology, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;

    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;

    Department of Anatomy, University of California, San Francisco, CA 94143;

    Departments of Cell Biology Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Departments of Oncology, Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205,Department of Anatomy, University of California, San Francisco, CA 94143;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 00:40:31

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