Expression cloning of Forssman glycolipid synthetase: A novel member of the histo-blood group ABO gene family

摘要

A phenotypic cloning approach was used to isolate a canine cDNA encoding Forssman glycolipid syn- thetase (FS; UDP-GalNAc:globoside -1,3-N-acetylgalac- tosaminyltransferase; EC 2.4.1.88). The deduced amino acid sequence of FS demonstrates extensive identity to three pre- viously cloned glycosyltransferases, including the enzymes responsible for synthesis of histo-blood group A and B antigens.