SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers

摘要

Transcriptional repression represents an im- portant component in the regulation of cell differentiation and oncogenesis mediated by nuclear hormone receptors. Hor- mones act to relieve repression, thus allowing receptors to function as transcriptional activators. The transcriptional corepressor SMRT was identified as a silencing mediator for retinoid and thyroid hormone receptors. SMRT is highly related to another corepressor, N-CoR, suggesting the exis- tence of a new family of receptor-interacting proteins.