Electroconvulsive shock and lidocaine reveal rapid consolidation of spatial working memory in the water maze

摘要

Head trauma leading to concussion and elec- troconvulsive shock (ECS) in humans causes amnesia for events that occurred shortly before the injury (retrograde amnesia). The present experiment investigated the amnesic effect of lidocaine and ECS in 25 rats trained on a working memory version of the Morris water task. Each day, the escape platform was moved to a new location; learning was evidenced by a decrease in the latency to find the platform from the first to the second trial.