Characterization of mouse angiogenin-related protein: Implications for functional studies on angiogenin

摘要

Angiogenin-related protein (Angrp), the pu- tative product of a recently discovered mouse gene, shares 78/100 sequence identity with mouse angiogenin (Ang). In the present study, the relationship of Angrp to Ang has been investigated by producing both proteins in bacteria and comparing their functional properties. We find that mouse Ang is potently angiogenic, but Angrp is not, even when assayed at relatively high doses.