A functional Rev-erbα responsive element located in the human Rev-erbα promoter mediates a repressing activity

摘要

Rev-erbα belongs to the nuclear receptor superfamily, which contains receptors for steroids, thyroid hormones, retinoic acid, and vitamin D, as well as "orphan" receptors. No ligand has been found for Rev-erbα to date, making it one of these orphan receptors. Similar to some other orphan receptors, Rev-erbα has been shown to bind DNA as a monomer on a specific sequence called a Rev-erbα respon- sive element (RevRE), but its transcriptional activity remains unclear.