CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis

摘要

We investigated the role of CD40-CD40 li- gand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurology- ical diseases. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates).