Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo

摘要

Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpoten- tial D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipitation studies indicate that INADa also binds to eye-specific protein kinase C and the phospholipase C, no-receptor-potential A (NORPA).