The RNA-binding protein, TB-RBP, is the mouse homologue of translin, a recombination protein associated with chromosomal translocations

摘要

The mouse RNA-binding protein, TB-RBP, suppresses translation in vitro and attaches mRNAs to micro- tubules by binding to conserved elements in the 3 untrans- lated regions of specific mRNAs. We have now purified TB-RBP from testicular and brain cytoplasmic extracts and cloned its cDNA. We find that the mouse TB-RBP cDNAs contain an open reading frame of 228 amino acids with a leucine zipper domain within its C terminus, a transmem- brane helix, and a group of putative phosphorylation sites.